Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest

Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stem cell-like cells. BMP signaling triggers cell-cycle exit and differentiation of GBM stem cells (GSCs) and, therefore, might have therapeutic value. However, the epigenetic mechanisms that accompany differentiation remain p...

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Bibliographic Details
Main Authors: Carén, Helena, Stricker, Stefan H., Bulstrode, Harry, Gagrica, Sladjana, Johnstone, Ewan, Bartlett, Thomas E., Feber, Andrew, Wilson, Gareth, Teschendorff, Andrew E., Bertone, Paul, Beck, Stephan, Pollard, Steven M.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649264/