Stem vs non-stem cell origin of colorectal cancer
Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt signalling pathway. Mutation of the adenomatous polyposis coli (APC) tumour suppressor gene, which encodes a protein that negatively regulates this pathway, occurs in almost...
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| Format: | Online |
| Language: | English |
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Nature Publishing Group
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647531/ |
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pubmed-46475312015-11-17 Stem vs non-stem cell origin of colorectal cancer Huels, D J Sansom, O J Minireview Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt signalling pathway. Mutation of the adenomatous polyposis coli (APC) tumour suppressor gene, which encodes a protein that negatively regulates this pathway, occurs in almost 80% of CRC cases. The progression of this cancer from an early adenoma to carcinoma is accompanied by a well-characterised set of mutations including KRAS, SMAD4 and TP53. Using elegant genetic models the current paradigm is that the intestinal stem cell is the origin of CRC. However, human histology and recent studies, showing marked plasticity within the intestinal epithelium, may point to other cells of origin. Here we will review these latest studies and place these in context to provide an up-to-date view of the cell of origin of CRC. Nature Publishing Group 2015-06-30 2015-06-25 /pmc/articles/PMC4647531/ /pubmed/26110974 http://dx.doi.org/10.1038/bjc.2015.214 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Huels, D J Sansom, O J |
| spellingShingle |
Huels, D J Sansom, O J Stem vs non-stem cell origin of colorectal cancer |
| author_facet |
Huels, D J Sansom, O J |
| author_sort |
Huels, D J |
| title |
Stem vs non-stem cell origin of colorectal cancer |
| title_short |
Stem vs non-stem cell origin of colorectal cancer |
| title_full |
Stem vs non-stem cell origin of colorectal cancer |
| title_fullStr |
Stem vs non-stem cell origin of colorectal cancer |
| title_full_unstemmed |
Stem vs non-stem cell origin of colorectal cancer |
| title_sort |
stem vs non-stem cell origin of colorectal cancer |
| description |
Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt signalling pathway. Mutation of the adenomatous polyposis coli (APC) tumour suppressor gene, which encodes a protein that negatively regulates this pathway, occurs in almost 80% of CRC cases. The progression of this cancer from an early adenoma to carcinoma is accompanied by a well-characterised set of mutations including KRAS, SMAD4 and TP53. Using elegant genetic models the current paradigm is that the intestinal stem cell is the origin of CRC. However, human histology and recent studies, showing marked plasticity within the intestinal epithelium, may point to other cells of origin. Here we will review these latest studies and place these in context to provide an up-to-date view of the cell of origin of CRC. |
| publisher |
Nature Publishing Group |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647531/ |
| _version_ |
1613502167521427456 |