USP4 Auto-Deubiquitylation Promotes Homologous Recombination
Repair of DNA double-strand breaks is crucial for maintaining genome integrity and is governed by post-translational modifications such as protein ubiquitylation. Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination. We also r...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643306/ |