Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Alzheimer’s disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in AD, we hypothesized that cyt...

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Bibliographic Details
Main Authors: Wood, Levi B., Winslow, Ashley R., Proctor, Elizabeth A., McGuone, Declan, Mordes, Daniel A., Frosch, Matthew P., Hyman, Bradley T., Lauffenburger, Douglas A., Haigis, Kevin M.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219/

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