Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer

Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is a major cause of death among breast cancer patients that results from intrinsic and acquired resistance to systemic chemotherapies. To identify novel targets for effective treatment of TNBC through combination strategies with MEK inhibitor (AS703026), we used...

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Bibliographic Details
Main Authors: Lee, Jangsoon, Galloway, Rachael, Grandjean, Geoff, Jacob, Justin, Humphries, Juliane, Bartholomeusz, Chandra, Goodstal, Samantha, Lim, Bora, Bartholomeusz, Geoffrey, Ueno, Naoto T., Rao, Arvind
Format: Online
Language:English
Published: Ivyspring International Publisher 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643087/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643087/

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