AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

AMIGO2 is a novel scaffold protein that regulates PDK1 membrane localization and Akt activation in endothelial cells, and inhibition of the interaction between PDK1–AMIGO2 results in impaired neovascularization, pathological angiogenesis, and tumor angiogenesis.

Bibliographic Details
Main Authors: Park, Hyojin, Lee, Sungwoon, Shrestha, Pravesh, Kim, Jihye, Park, Jeong Ae, Ko, Yeongrim, Ban, Young Ho, Park, Dae-Young, Ha, Sang-Jun, Koh, Gou Young, Hong, Victor Sukbong, Mochizuki, Naoki, Kim, Young-Myeong, Lee, Weontae, Kwon, Young-Guen
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639856/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639856/

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