Extravascular lung water in critical care: recent advances and clinical applications

Extravascular lung water (EVLW) is the amount of fluid that is accumulated in the interstitial and alveolar spaces. In lung oedema, EVLW increases either because of increased lung permeability or because of increased hydrostatic pressure in the pulmonary capillaries, or both. Increased EVLW is alway...

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Main Authors:	Jozwiak, Mathieu, Teboul, Jean-Louis, Monnet, Xavier
Format:	Online
Language:	English
Published:	Springer Paris 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636545/

id	pubmed-4636545
recordtype	oai_dc
spelling	pubmed-46365452015-11-12 Extravascular lung water in critical care: recent advances and clinical applications Jozwiak, Mathieu Teboul, Jean-Louis Monnet, Xavier Review Extravascular lung water (EVLW) is the amount of fluid that is accumulated in the interstitial and alveolar spaces. In lung oedema, EVLW increases either because of increased lung permeability or because of increased hydrostatic pressure in the pulmonary capillaries, or both. Increased EVLW is always potentially life-threatening, mainly because it impairs gas exchange and reduces lung compliance. The only technique that provides an easy measurement of EVLW at the bedside is transpulmonary thermodilution. The validation of EVLW measurements by thermodilution was based on studies showing reasonable correlations with gravimetry or thermo-dye dilution in experimental and clinical studies. EVLW should be indexed to predicted body weight. This indexation reduces the proportion of ARDS patients for whom EVLW is in the normal range. Compared to non-indexed EVLW, indexed EVLW (EVLWI) is better correlated with the lung injury score and the oxygenation and it is a better predictor of mortality of patients with acute lung injury or acute respiratory distress syndrome (ARDS). Transpulmonary thermodilution also provides the pulmonary vascular permeability index (PVPI), which is an indirect reflection of the integrity of the alveolocapillary barrier. As clinical applications, EVLWI and PVPI may be useful to guide fluid management of patients at risk of fluid overload, as during septic shock and ARDS. High EVLWI and PVPI values predict mortality in several categories of critically ill patients, especially during ARDS. Thus, fluid administration should be limited when EVLWI is already high. Whatever the value of EVLWI, PVPI may indicate that fluid administration is particularly at risk of aggravating lung oedema. In the acute phase of haemodynamic resuscitation during septic shock and ARDS, high EVLWI and PVPI values may warn of the risk of fluid overload and prevent excessive volume expansion. At the post-resuscitation phase, they may prompt initiation of fluid removal thereby achieving a negative fluid balance. Springer Paris 2015-11-06 /pmc/articles/PMC4636545/ /pubmed/26546321 http://dx.doi.org/10.1186/s13613-015-0081-9 Text en © Jozwiak et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jozwiak, Mathieu Teboul, Jean-Louis Monnet, Xavier
spellingShingle	Jozwiak, Mathieu Teboul, Jean-Louis Monnet, Xavier Extravascular lung water in critical care: recent advances and clinical applications
author_facet	Jozwiak, Mathieu Teboul, Jean-Louis Monnet, Xavier
author_sort	Jozwiak, Mathieu
title	Extravascular lung water in critical care: recent advances and clinical applications
title_short	Extravascular lung water in critical care: recent advances and clinical applications
title_full	Extravascular lung water in critical care: recent advances and clinical applications
title_fullStr	Extravascular lung water in critical care: recent advances and clinical applications
title_full_unstemmed	Extravascular lung water in critical care: recent advances and clinical applications
title_sort	extravascular lung water in critical care: recent advances and clinical applications
description	Extravascular lung water (EVLW) is the amount of fluid that is accumulated in the interstitial and alveolar spaces. In lung oedema, EVLW increases either because of increased lung permeability or because of increased hydrostatic pressure in the pulmonary capillaries, or both. Increased EVLW is always potentially life-threatening, mainly because it impairs gas exchange and reduces lung compliance. The only technique that provides an easy measurement of EVLW at the bedside is transpulmonary thermodilution. The validation of EVLW measurements by thermodilution was based on studies showing reasonable correlations with gravimetry or thermo-dye dilution in experimental and clinical studies. EVLW should be indexed to predicted body weight. This indexation reduces the proportion of ARDS patients for whom EVLW is in the normal range. Compared to non-indexed EVLW, indexed EVLW (EVLWI) is better correlated with the lung injury score and the oxygenation and it is a better predictor of mortality of patients with acute lung injury or acute respiratory distress syndrome (ARDS). Transpulmonary thermodilution also provides the pulmonary vascular permeability index (PVPI), which is an indirect reflection of the integrity of the alveolocapillary barrier. As clinical applications, EVLWI and PVPI may be useful to guide fluid management of patients at risk of fluid overload, as during septic shock and ARDS. High EVLWI and PVPI values predict mortality in several categories of critically ill patients, especially during ARDS. Thus, fluid administration should be limited when EVLWI is already high. Whatever the value of EVLWI, PVPI may indicate that fluid administration is particularly at risk of aggravating lung oedema. In the acute phase of haemodynamic resuscitation during septic shock and ARDS, high EVLWI and PVPI values may warn of the risk of fluid overload and prevent excessive volume expansion. At the post-resuscitation phase, they may prompt initiation of fluid removal thereby achieving a negative fluid balance.
publisher	Springer Paris
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636545/
_version_	1613498671145418752

Extravascular lung water in critical care: recent advances and clinical applications

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