Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Cancer-associated muscle weakness is poorly understood and there is no effective treatment. Here, we find that seven different mouse models of human osteolytic bone metastases, representing breast, lung and prostate cancers, as well as multiple myeloma exhibited impaired muscle function, implicating...

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Bibliographic Details
Main Authors: Waning, David L., Mohammad, Khalid S., Reiken, Steven, Xie, Wenjun, Andersson, Daniel C., John, Sutha, Chiechi, Antonella, Wright, Laura E., Umanskaya, Alisa, Niewolna, Maria, Trivedi, Trupti, Charkhzarrin, Sahba, Khatiwada, Pooja, Wronska, Anetta, Haynes, Ashley, Benassi, Maria Serena, Witzmann, Frank A., Zhen, Gehua, Wang, Xiao, Cao, Xu, Roodman, G. David, Marks, Andrew R., Guise, Theresa A.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636436/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636436/

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