Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma

C-X-C chemokine receptor 2 (CXCR2), a member of the G-protein-coupled receptor family, is an interleukin-8 receptor and results in the activation of neutrophils. To date, CXCR2 has been identified with many cell events, including inflammation, neovascularization, metastasis, and cell carcinogenesis....

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Main Authors:	Yang, Liu, Liu, Zenghui, Wu, Ronghua, Yao, Qi, Gu, Zhikai, Liu, Mei
Format:	Online
Language:	English
Published:	Dove Medical Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636088/

id	pubmed-4636088
recordtype	oai_dc
spelling	pubmed-46360882015-11-19 Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma Yang, Liu Liu, Zenghui Wu, Ronghua Yao, Qi Gu, Zhikai Liu, Mei Original Research C-X-C chemokine receptor 2 (CXCR2), a member of the G-protein-coupled receptor family, is an interleukin-8 receptor and results in the activation of neutrophils. To date, CXCR2 has been identified with many cell events, including inflammation, neovascularization, metastasis, and cell carcinogenesis. This study aimed to investigate alterations in the expression of CXCR2 in patients with brain gliomas and relationships with pathological grades and clinicopathological characteristics. Brain tissue specimens from 60 patients with glioma and 15 patients undergoing surgery for epilepsy (controls) were detected using streptavidin-perosidase immunohistochemistry. Western blotting was used to evaluate CXCR2 protein levels with fresh tissues derived from glioma cases or controls. Correlations between CXCR2 expression and clinicopathological characteristics were analyzed using SPSS software. The results showed high-grade gliomas with high CXCR2 expression as compared with normal tissues. The expression of CXCR2 was significantly related to high grades and recurrence of tumor but not to age or sex. During an in vitro wound healing assay, U251 migration was reduced when the CXCR2-specific inhibitor SB225002 was applied. Our results suggested that the high expression of CXCR2 in gliomas was closely correlated to the degree of malignancy and recurrence and that CXCR2 inhibition decreased the migration of glioma cells. Therefore, CXCR2 may serve as a potential therapeutic target for the recurrence and migration of gliomas. Dove Medical Press 2015-11-02 /pmc/articles/PMC4636088/ /pubmed/26586954 http://dx.doi.org/10.2147/OTT.S91626 Text en © 2015 Yang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Liu Liu, Zenghui Wu, Ronghua Yao, Qi Gu, Zhikai Liu, Mei
spellingShingle	Yang, Liu Liu, Zenghui Wu, Ronghua Yao, Qi Gu, Zhikai Liu, Mei Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
author_facet	Yang, Liu Liu, Zenghui Wu, Ronghua Yao, Qi Gu, Zhikai Liu, Mei
author_sort	Yang, Liu
title	Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
title_short	Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
title_full	Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
title_fullStr	Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
title_full_unstemmed	Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
title_sort	correlation of c-x-c chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma
description	C-X-C chemokine receptor 2 (CXCR2), a member of the G-protein-coupled receptor family, is an interleukin-8 receptor and results in the activation of neutrophils. To date, CXCR2 has been identified with many cell events, including inflammation, neovascularization, metastasis, and cell carcinogenesis. This study aimed to investigate alterations in the expression of CXCR2 in patients with brain gliomas and relationships with pathological grades and clinicopathological characteristics. Brain tissue specimens from 60 patients with glioma and 15 patients undergoing surgery for epilepsy (controls) were detected using streptavidin-perosidase immunohistochemistry. Western blotting was used to evaluate CXCR2 protein levels with fresh tissues derived from glioma cases or controls. Correlations between CXCR2 expression and clinicopathological characteristics were analyzed using SPSS software. The results showed high-grade gliomas with high CXCR2 expression as compared with normal tissues. The expression of CXCR2 was significantly related to high grades and recurrence of tumor but not to age or sex. During an in vitro wound healing assay, U251 migration was reduced when the CXCR2-specific inhibitor SB225002 was applied. Our results suggested that the high expression of CXCR2 in gliomas was closely correlated to the degree of malignancy and recurrence and that CXCR2 inhibition decreased the migration of glioma cells. Therefore, CXCR2 may serve as a potential therapeutic target for the recurrence and migration of gliomas.
publisher	Dove Medical Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636088/
_version_	1613498490997964800

Correlation of C-X-C chemokine receptor 2 upregulation with poor prognosis and recurrence in human glioma

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