Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Inhibitor studies with isolated mitochondria demonstrated that complex I (CI) and III (CIII) of the electron transport chain (ETC) can act as relevant sources of mitochondrial reactive oxygen species (ROS). Here we studied ROS generation and oxidative stress induction during chronic (24 h) inhibitio...

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Bibliographic Details
Main Authors: Forkink, Marleen, Basit, Farhan, Teixeira, José, Swarts, Herman G., Koopman, Werner J.H., Willems, Peter H.G.M.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635408/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635408/

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