Multiple Origins of Mutations in the mdr1 Gene—A Putative Marker of Chloroquine Resistance in P. vivax

Multiple Origins of Mutations in the mdr1 Gene—A Putative Marker of Chloroquine Resistance in P. vivax

Chloroquine combined with primaquine has been the recommended antimalarial treatment for Plasmodium vivax malaria infections for sixty years but the efficacy of this treatment regimen is threatened by chloroquine resistance. In this study we describe the prevalence of mutations in the P. vivax gene,...

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Main Authors: Schousboe, Mette L., Ranjitkar, Samir, Rajakaruna, Rupika S., Amerasinghe, Priyanie H., Morales, Francisco, Pearce, Richard, Ord, Rosalyn, Leslie, Toby, Rowland, Mark, Gadalla, Nahla B., Konradsen, Flemming, Bygbjerg, Ib C., Roper, Cally, Alifrangis, Michael
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634971/

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