Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae
Cholera pathogenesis occurs due to synergistic pro-secretory effects of several toxins, such as cholera toxin (CTX) and Accessory cholera enterotoxin (Ace) secreted by Vibrio cholerae strains. Ace activates chloride channels stimulating chloride/bicarbonate transport that augments fluid secretion re...
Main Authors: | , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
Public Library of Science
2015
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634967/ |