Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium

Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling. We studied effe...

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Bibliographic Details
Main Authors: Feng, Ying, Sakamoto, Naoya, Wu, Rong, Liu, Jie-yu, Wiese, Alexandra, Green, Maranne E., Green, Megan, Akyol, Aytekin, Roy, Badal C., Zhai, Yali, Cho, Kathleen R., Fearon, Eric R.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631511/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631511/

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