Longevity GWAS Using the Drosophila Genetic Reference Panel

Longevity GWAS Using the Drosophila Genetic Reference Panel

We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a genome-wide association analysis for virgin female lifespan, using ~2M common single nucleotide polymorphisms (SNPs). We found considerable genetic variation in lifespan in the DGRP, with a broad-sense heritability...

Full description

Bibliographic Details
Main Authors:	Ivanov, Dobril K., Escott-Price, Valentina, Ziehm, Matthias, Magwire, Michael M., Mackay, Trudy F. C., Partridge, Linda, Thornton, Janet M.
Format:	Online
Language:	English
Published:	Oxford University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631106/

Similar Items

Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c3mb25485bClick here for additional data file.
by: Ivanov, Dobril K., et al.
Published: (2013)

SurvCurv database and online survival analysis platform update
by: Ziehm, Matthias, et al.
Published: (2015)

The Drosophila melanogaster Genetic Reference Panel
by: Mackay, Trudy F. C., et al.
Published: (2012)

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
by: Castillo-Quan, Jorge Iván, et al.
Published: (2016)

Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data
by: Ziehm, Matthias, et al.
Published: (2013)

Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv
by: Ziehm, Matthias, et al.
Published: (2013)

Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing
by: Papatheodorou, Irene, et al.
Published: (2012)

Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster
by: Dembeck, Lauren M., et al.
Published: (2015)

Indy Mutations and Drosophila Longevity
by: Rogina, Blanka, et al.
Published: (2013)

The Genetic Basis for Variation in Olfactory Behavior in Drosophila melanogaster
by: Arya, Gunjan H., et al.
Published: (2015)

Correction: Accounting for Genetic Architecture Improves Sequence Based Genomic Prediction for a Drosophila Fitness Trait
by: Ober, Ulrike, et al.
Published: (2015)

Accounting for Genetic Architecture Improves Sequence Based Genomic Prediction for a Drosophila Fitness Trait
by: Ober, Ulrike, et al.
Published: (2015)

Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster
by: Jordan, Katherine W., et al.
Published: (2012)

Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster
by: Weber, Allison L., et al.
Published: (2012)

The Effects of Royal Jelly on Fitness Traits and Gene Expression in Drosophila melanogaster
by: Shorter, John R., et al.
Published: (2015)

Linkage Disequilibrium and Inversion-Typing of the Drosophila melanogaster Genome Reference Panel
by: Houle, David, et al.
Published: (2015)

Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors
by: Mejia, Jonathan, et al.
Published: (2012)

Glucose modulates Drosophila longevity and immunity independent of the microbiota
by: Galenza, Anthony, et al.
Published: (2016)

Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures
by: Yashin, Anatoliy I., et al.
Published: (2016)

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
by: Deelen, Joris, et al.
Published: (2011)

The genetic basis of natural variation in mushroom body size in Drosophila melanogaster
by: Zwarts, Liesbeth, et al.
Published: (2015)

The Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome Reveals a Network of Epistatic Fitness Interactions
by: Pool, John E.
Published: (2015)

Translating longevity research into healthspan
by: Lithgow, Gordon J, et al.
Published: (2012)

Digesting GWAS
by: Turnpenny, Peter D.
Published: (2016)

Quantitative genomics of starvation stress resistance in Drosophila
by: Harbison, Susan T, et al.
Published: (2005)

Transcriptional response to alcohol exposure in Drosophila melanogaster
by: Morozova, Tatiana V, et al.
Published: (2006)

Genome-wide association study of sleep in Drosophila melanogaster
by: Harbison, Susan T, et al.
Published: (2013)

Transcriptional and epigenetic responses to mating and aging in Drosophila melanogaster
by: Zhou, Shanshan, et al.
Published: (2014)

Reference-based phasing using the Haplotype Reference Consortium panel
by: Loh, Po-Ru, et al.
Published: (2016)

Hope for GWAS: Relevant Risk Genes Uncovered from GWAS Statistical Noise
by: Correia, Catarina, et al.
Published: (2014)

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity
by: Slack, Cathy, et al.
Published: (2015)

Phenotypic Plasticity of the Drosophila Transcriptome
by: Zhou, Shanshan, et al.
Published: (2012)

Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data
by: Sanjak, Jaleal S., et al.
Published: (2016)

Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results
by: Priyadarshini, S., et al.
Published: (2010)

Genome-Wide Association Study of Extreme Longevity in Drosophila melanogaster
by: Burke, Molly K., et al.
Published: (2013)

Rpd3 interacts with insulin signaling in Drosophila longevity extension
by: Woods, Jared K., et al.
Published: (2016)

Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms
by: Sujkowski, Alyson, et al.
Published: (2015)

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity
by: Danilov, Anton, et al.
Published: (2015)

Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila
by: Xia, Brian, et al.
Published: (2016)

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
by: Morozova, Tatiana V, et al.
Published: (2007)