Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid

Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid

Primary effusion lymphoma (PEL) in patients with Human Immunodeficiency Virus (HIV) infection may involve pleural, pericardial, and peritoneal cavities. PEL involving the cerebrospinal fluid (CSF) is exceedingly rare, and to our knowledge has only been reported in two cases. We report another case o...

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Main Authors: Jain, Sarika, Palekar, Alka, Monaco, Sara E., Craig, Fiona E., Bejjani, Ghassan, Pantanowitz, Liron
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630777/
id pubmed-4630777
recordtype oai_dc
spelling pubmed-46307772015-11-24 Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid Jain, Sarika Palekar, Alka Monaco, Sara E. Craig, Fiona E. Bejjani, Ghassan Pantanowitz, Liron Case Report Primary effusion lymphoma (PEL) in patients with Human Immunodeficiency Virus (HIV) infection may involve pleural, pericardial, and peritoneal cavities. PEL involving the cerebrospinal fluid (CSF) is exceedingly rare, and to our knowledge has only been reported in two cases. We report another case of PEL diagnosed in CSF from a 61-year-old male with Acquired Immunodeficiency Syndrome that presented with neurological symptoms. Imaging studies of his brain showed leptomeningeal/periventricular enhancement, but no mass lesion. His CSF demonstrated human herpesvirus-8 positive pleomorphic lymphoplasmacytoid cells of null cell phenotype. This case highlights that albeit rare, PEL should be included in the differential diagnosis when large atypical cells are encountered in CSF of HIV-positive patients, even when such patients have no history of lymphoma. As in this case, ancillary studies are required to make an accurate diagnosis of PEL in CSF cytology. Medknow Publications & Media Pvt Ltd 2015-10-23 /pmc/articles/PMC4630777/ /pubmed/26604975 http://dx.doi.org/10.4103/1742-6413.168059 Text en Copyright: © 2015 Jain, et al.; Licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Jain, Sarika
Palekar, Alka
Monaco, Sara E.
Craig, Fiona E.
Bejjani, Ghassan
Pantanowitz, Liron
spellingShingle Jain, Sarika
Palekar, Alka
Monaco, Sara E.
Craig, Fiona E.
Bejjani, Ghassan
Pantanowitz, Liron
Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
author_facet Jain, Sarika
Palekar, Alka
Monaco, Sara E.
Craig, Fiona E.
Bejjani, Ghassan
Pantanowitz, Liron
author_sort Jain, Sarika
title Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
title_short Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
title_full Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
title_fullStr Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
title_full_unstemmed Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid
title_sort human immunodeficiency virus-associated primary effusion lymphoma: an exceedingly rare entity in cerebrospinal fluid
description Primary effusion lymphoma (PEL) in patients with Human Immunodeficiency Virus (HIV) infection may involve pleural, pericardial, and peritoneal cavities. PEL involving the cerebrospinal fluid (CSF) is exceedingly rare, and to our knowledge has only been reported in two cases. We report another case of PEL diagnosed in CSF from a 61-year-old male with Acquired Immunodeficiency Syndrome that presented with neurological symptoms. Imaging studies of his brain showed leptomeningeal/periventricular enhancement, but no mass lesion. His CSF demonstrated human herpesvirus-8 positive pleomorphic lymphoplasmacytoid cells of null cell phenotype. This case highlights that albeit rare, PEL should be included in the differential diagnosis when large atypical cells are encountered in CSF of HIV-positive patients, even when such patients have no history of lymphoma. As in this case, ancillary studies are required to make an accurate diagnosis of PEL in CSF cytology.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630777/
_version_ 1613496523346149376

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