Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease

Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease

The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the regulation of HMGB1 in NAFLD, particularly through sirtuin 1 (SIRT1), remains unclear. In this study, we investigated the role of SIRT1-med...

Full description

Bibliographic Details
Main Authors: Zeng, Wenjing, Shan, Wen, Gao, Lili, Gao, Dongyan, Hu, Yan, Wang, Guangzhi, Zhang, Ning, Li, Zhenlu, Tian, Xiaofeng, Xu, Wei, Peng, Jinyong, Ma, Xiaochi, Yao, Jihong
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630617/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630617/

Similar Items