Defining severe asthma – an approach to find new therapies
Asthma is a chronic inflammatory disease that has reached epidemic proportions worldwide. It is treatable in the majority of patients, but there is no cure. Moreover, a proportion of patients suffer from severe, difficult-to-control disease with daily symptoms and high morbidity, making it imperativ...
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| Format: | Online |
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Co-Action Publishing
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629770/ |
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pubmed-46297702015-11-09 Defining severe asthma – an approach to find new therapies Nanzer, Alexandra M. Menzies-Gow, Andrew Review Article Asthma is a chronic inflammatory disease that has reached epidemic proportions worldwide. It is treatable in the majority of patients, but there is no cure. Moreover, a proportion of patients suffer from severe, difficult-to-control disease with daily symptoms and high morbidity, making it imperative that we continue to improve our understanding of the underlying mechanisms of this disease. Severe asthma is a heterogeneous condition. A systematic approach to identify specific asthma phenotypes, including clinical characteristics and inflammatory processes, is the first step toward individualized, logical therapy. This review focuses on the need to characterize severe asthma phenotypes and on novel, targeted molecular treatment options currently under development. Co-Action Publishing 2014-06-05 /pmc/articles/PMC4629770/ /pubmed/26557245 http://dx.doi.org/10.3402/ecrj.v1.24356 Text en © 2014 Alexandra M. Nanzer and Andrew Menzies-Gow http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Nanzer, Alexandra M. Menzies-Gow, Andrew |
| spellingShingle |
Nanzer, Alexandra M. Menzies-Gow, Andrew Defining severe asthma – an approach to find new therapies |
| author_facet |
Nanzer, Alexandra M. Menzies-Gow, Andrew |
| author_sort |
Nanzer, Alexandra M. |
| title |
Defining severe asthma – an approach to find new therapies |
| title_short |
Defining severe asthma – an approach to find new therapies |
| title_full |
Defining severe asthma – an approach to find new therapies |
| title_fullStr |
Defining severe asthma – an approach to find new therapies |
| title_full_unstemmed |
Defining severe asthma – an approach to find new therapies |
| title_sort |
defining severe asthma – an approach to find new therapies |
| description |
Asthma is a chronic inflammatory disease that has reached epidemic proportions worldwide. It is treatable in the majority of patients, but there is no cure. Moreover, a proportion of patients suffer from severe, difficult-to-control disease with daily symptoms and high morbidity, making it imperative that we continue to improve our understanding of the underlying mechanisms of this disease. Severe asthma is a heterogeneous condition. A systematic approach to identify specific asthma phenotypes, including clinical characteristics and inflammatory processes, is the first step toward individualized, logical therapy. This review focuses on the need to characterize severe asthma phenotypes and on novel, targeted molecular treatment options currently under development. |
| publisher |
Co-Action Publishing |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629770/ |
| _version_ |
1613496188352331776 |