3-D structural analysis of the crucial intermediate of skeletal muscle myosin and its role in revised actomyosin cross-bridge cycle
Skeletal myosin S1 consists of two functional segments, a catalytic-domain and a lever-arm. Since the crystal structure of ADP/Vi-bound S1 exhibits a strong intramolecular flexure between two segments, inter-conversion between bent and extended forms; i.e. “tilting of the lever-arm” has been accepte...
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| Format: | Online |
| Language: | English |
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The Biophysical Society of Japan (BSJ)
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629655/ |