Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload

Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload

Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD+) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD+ by monocyte-derived e...

Full description

Bibliographic Details
Main Authors: Yano, Masamichi, Akazawa, Hiroshi, Oka, Toru, Yabumoto, Chizuru, Kudo-Sakamoto, Yoko, Kamo, Takehiro, Shimizu, Yu, Yagi, Hiroki, Naito, Atsuhiko T., Lee, Jong-Kook, Suzuki, Jun-ichi, Sakata, Yasushi, Komuro, Issei
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629142/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629142/

Similar Items