Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces

Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces

Protein-protein interactions (PPIs) play a major role in many biological processes and they represent an important class of targets for therapeutic intervention. However, targeting PPIs is challenging because often no convenient natural substrates are available as starting point for small-molecule d...

Full description

Bibliographic Details
Main Authors:	Mohamed, Ruzianisra, Degac, Jennifer, Helms, Volkhard
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627654/

Similar Items

Predicting where Small Molecules Bind at Protein-Protein Interfaces
by: Walter, Peter, et al.
Published: (2013)

Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare
by: Thorsten Will, et al.
Published: (2017-04-01)

Prediction of the burial status of transmembrane residues of helical membrane proteins
by: Park, Yungki, et al.
Published: (2007)

Interolog interfaces in protein–protein docking
by: Alsop, James D., et al.
Published: (2015)

Anchored Design of Protein-Protein Interfaces
by: Lewis, Steven M., et al.
Published: (2011)

Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces
by: Bohnuud, Tanggis, et al.
Published: (2014)

Multifunctional proteins revealed by overlapping clustering in protein interaction network
by: Becker, Emmanuelle, et al.
Published: (2012)

An overlapping module identification method in protein-protein interaction networks
by: Wang, Xuesong, et al.
Published: (2012)

Cavities in protein–DNA and protein–RNA interfaces
by: Sonavane, Shrihari, et al.
Published: (2009)

SCOPPI: a structural classification of protein–protein interfaces
by: Winter, Christof, et al.
Published: (2006)

Identification of hot spot residues at protein-protein interface
by: Li, Lei, et al.
Published: (2006)

Towards targeting protein-protein interfaces with small molecules
by: Gohlke, Holger, et al.
Published: (2011)

Alternative Protein-Protein Interfaces Are Frequent Exceptions
by: Hamp, Tobias, et al.
Published: (2012)

Interface-Resolved Network of Protein-Protein Interactions
by: Johnson, Margaret E., et al.
Published: (2013)

Local Network Patterns in Protein-Protein Interfaces
by: Luo, Qiang, et al.
Published: (2013)

Anatomy of β-Strands at Protein–Protein Interfaces
by: Watkins, Andrew M., et al.
Published: (2014)

Characterization of Protein–Protein Interfaces through a Protein Contact Network Approach
by: Di Paola, Luisa, et al.
Published: (2015)

Protein docking prediction using predicted protein-protein interface
by: Li, Bin, et al.
Published: (2012)

Predictions of Protein-Protein Interfaces within Membrane Protein Complexes
by: Asadabadi, Ebrahim Barzegari, et al.
Published: (2013)

Implication of Terminal Residues at Protein-Protein and Protein-DNA Interfaces
by: Martin, Olivier M. F., et al.
Published: (2016)

Exploring the Composition of Protein-Ligand Binding Sites on a Large Scale
by: Khazanov, Nickolay A., et al.
Published: (2013)

Chaperonin GroEL Reassembly: An Effect of Protein Ligands and Solvent Composition
by: Ryabova, Nataliya, et al.
Published: (2014)

Detecting Overlapping Protein Complexes by Rough-Fuzzy Clustering in Protein-Protein Interaction Networks
by: Wu, Hao, et al.
Published: (2014)

Identifying Hierarchical and Overlapping Protein Complexes Based on Essential Protein-Protein Interactions and “Seed-Expanding” Method
by: Ren, Jun, et al.
Published: (2014)

Design of Multi-Specificity in Protein Interfaces
by: Humphris, Elisabeth L, et al.
Published: (2007)

Protein interface classification by evolutionary analysis
by: Duarte, Jose M, et al.
Published: (2012)

An analysis of oligomerization interfaces in transmembrane proteins
by: Duarte, Jose M, et al.
Published: (2013)

Bioinformatic analysis of the protein/DNA interface
by: Schneider, Bohdan, et al.
Published: (2014)

Protein sorting at the ER–Golgi interface
by: Gomez-Navarro, Natalia, et al.
Published: (2016)

Progress and challenges in predicting protein interfaces
by: Esmaielbeiki, Reyhaneh, et al.
Published: (2016)

Voltammetry of proteins at liquid-liquid interfaces
by: Arrigan, Damien
Published: (2013)

Artificial Affinity Proteins as Ligands of Immunoglobulins
by: Mouratou, Barbara, et al.
Published: (2015)

Ligand recognition by the major urinary protein
by: Roy, Julie
Published: (2012)

PLIC: protein–ligand interaction clusters
by: Anand, Praveen, et al.
Published: (2014)

The use of supramolecular structures as protein ligands
by: Stopa, Barbara, et al.
Published: (2013)

The influence of protonation in protein-ligand docking
by: Brink, ten T, et al.
Published: (2008)

Ligand-protein docking with water molecules
by: Roberts, Benjamin, et al.
Published: (2008)

Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin
by: Fuchs, Julian E., et al.
Published: (2015)

Flexibility and small pockets at protein–protein interfaces: New insights into druggability
by: Jubb, Harry, et al.
Published: (2015)

PCalign: a method to quantify physicochemical similarity of protein-protein interfaces
by: Cheng, Shanshan, et al.
Published: (2015)