Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit

Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit

Some feedback pathways are critical in the process of tumor development or malignant progression. However the mechanisms through which these pathways are epigenetically regulated have not been fully elucidated. Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-β1-(p-Smad3)-...

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Bibliographic Details
Main Authors: Liang, Xiuming, Zeng, Jiping, Wang, Lixiang, Shen, Li, Ma, Xueping, Li, Shuyan, Wu, Yujiao, Ma, Lin, Ci, Xinyu, Guo, Qing, Jia, Mutian, Shen, Haiyu, Sun, Yundong, Liu, Zhifang, Liu, Shili, Li, Wenjuan, Yu, Han, Chen, Chunyan, Jia, Jihui
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627336/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627336/

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