The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells

The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells

Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide and its advanced status is frequently resistant to conventional chemotherapeutic agents and radiation. We evaluated the cytotoxic effect of the orally bioavailable dual PI3K/mTOR inhibitor, NVP-BGT226, on a...

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Bibliographic Details
Main Authors: Simioni, Carolina, Cani, Alice, Martelli, Alberto M., Zauli, Giorgio, Alameen, Ayman A.M., Ultimo, Simona, Tabellini, Giovanna, McCubrey, James A., Capitani, Silvano, Neri, Luca M.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627298/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627298/

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