Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis

Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis

Using in vitro and in vivo models, we investigated the role of TFF1 in suppressing H. pylori-mediated activation of oncogenic β-catenin in gastric tumorigenesis. A reconstitution of TFF1 expression in gastric cancer cells decreased H. pylori-induced β-catenin nuclear translocation, as compared to co...

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Bibliographic Details
Main Authors: Soutto, Mohammed, Romero-Gallo, Judith, Krishna, Uma, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Peek, Richard M., El-Rifai, Wael
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627225/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627225/

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