Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

Aberrations in the mTOR (mechanistic target of rapamycin) axis are frequently reported in cancer. Using publicly available tumor genome sequencing data, we identified several point mutations in MTOR and its upstream regulator RHEB (Ras homolog enriched in brain) in patients with clear cell renal cel...

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Bibliographic Details
Main Authors: Ghosh, Arindam P., Marshall, Christopher B., Coric, Tatjana, Shim, Eun-hee, Kirkman, Richard, Ballestas, Mary E., Ikura, Mitsuhiko, Bjornsti, Mary-Ann, Sudarshan, Sunil
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627224/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627224/

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