An extended dsRBD is required for post-transcriptional modification in human tRNAs

An extended dsRBD is required for post-transcriptional modification in human tRNAs

In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2). Human Dus2 (HsDus2) expression is upregulated in lung cancers, offering a growth a...

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Bibliographic Details
Main Authors: Bou-Nader, Charles, Pecqueur, Ludovic, Bregeon, Damien, Kamah, Amina, Guérineau, Vincent, Golinelli-Pimpaneau, Béatrice, Guimarães, Beatriz G., Fontecave, Marc, Hamdane, Djemel
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627097/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627097/

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