Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection

The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. However, the significance of circulating miRNAs in upper tract urothelial carcinoma (UTUC) has remained to be investigated. The present study perfo...

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Main Authors:	TAO, JUN, YANG, XIAO, LI, PENGCHAO, WEI, JIFU, DENG, XIAHENG, CHENG, YIDONG, QIN, CHAO, JU, XIAOBING, MENG, XIAOXIN, LI, JIE, GU, MIN, LU, QIANG, YIN, CHANGJUN
Format:	Online
Language:	English
Published:	D.A. Spandidos 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626156/

id	pubmed-4626156
recordtype	oai_dc
spelling	pubmed-46261562016-02-23 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection TAO, JUN YANG, XIAO LI, PENGCHAO WEI, JIFU DENG, XIAHENG CHENG, YIDONG QIN, CHAO JU, XIAOBING MENG, XIAOXIN LI, JIE GU, MIN LU, QIANG YIN, CHANGJUN Articles The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. However, the significance of circulating miRNAs in upper tract urothelial carcinoma (UTUC) has remained to be investigated. The present study performed a genome wide serum miRNA analysis using a deep sequencing platform for initial screening. Subsequently, serum samples of 46 UTUC patients and 30 cancer free individuals with hematuria were subjected to a quantitative reverse transcription polymerase chain reaction analysis. The expression of thirteen miRNAs (miR-664a-3p, miR-423-5p, miR-431-5p, miR-191-5p, miR-92a-3p, miR-22-3p, miR-26a-5p, miR-33b-3p, miR-16-5p, let-7a 5p, let-7b-5p, let-7f-5p and let-7c) was significantly different in serum from UTUC patients compared with that in control samples. Receiver operator characteristic analysis showed that 10 miRNAs (miR-664a-3p, miR-431-5p, miR-423-5p, miR-191-5p, miR-33b-3p, miR-26a-5p, miR-22-3p, miR-16-5p, let-7b-5p and let-7c) had the potential to distinguish individuals with UTUC from the controls (areas under the curve >0.8). The present study provided the first evidence for the potential use of circulating miRNAs as biomarkers for UTUC diagnosis, which remains to be verified by further studies. D.A. Spandidos 2015-11 2015-08-27 /pmc/articles/PMC4626156/ /pubmed/26323574 http://dx.doi.org/10.3892/mmr.2015.4257 Text en Copyright: © Tao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	TAO, JUN YANG, XIAO LI, PENGCHAO WEI, JIFU DENG, XIAHENG CHENG, YIDONG QIN, CHAO JU, XIAOBING MENG, XIAOXIN LI, JIE GU, MIN LU, QIANG YIN, CHANGJUN
spellingShingle	TAO, JUN YANG, XIAO LI, PENGCHAO WEI, JIFU DENG, XIAHENG CHENG, YIDONG QIN, CHAO JU, XIAOBING MENG, XIAOXIN LI, JIE GU, MIN LU, QIANG YIN, CHANGJUN Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
author_facet	TAO, JUN YANG, XIAO LI, PENGCHAO WEI, JIFU DENG, XIAHENG CHENG, YIDONG QIN, CHAO JU, XIAOBING MENG, XIAOXIN LI, JIE GU, MIN LU, QIANG YIN, CHANGJUN
author_sort	TAO, JUN
title	Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
title_short	Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
title_full	Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
title_fullStr	Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
title_full_unstemmed	Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
title_sort	identification of circulating microrna signatures for upper tract urothelial carcinoma detection
description	The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. However, the significance of circulating miRNAs in upper tract urothelial carcinoma (UTUC) has remained to be investigated. The present study performed a genome wide serum miRNA analysis using a deep sequencing platform for initial screening. Subsequently, serum samples of 46 UTUC patients and 30 cancer free individuals with hematuria were subjected to a quantitative reverse transcription polymerase chain reaction analysis. The expression of thirteen miRNAs (miR-664a-3p, miR-423-5p, miR-431-5p, miR-191-5p, miR-92a-3p, miR-22-3p, miR-26a-5p, miR-33b-3p, miR-16-5p, let-7a 5p, let-7b-5p, let-7f-5p and let-7c) was significantly different in serum from UTUC patients compared with that in control samples. Receiver operator characteristic analysis showed that 10 miRNAs (miR-664a-3p, miR-431-5p, miR-423-5p, miR-191-5p, miR-33b-3p, miR-26a-5p, miR-22-3p, miR-16-5p, let-7b-5p and let-7c) had the potential to distinguish individuals with UTUC from the controls (areas under the curve >0.8). The present study provided the first evidence for the potential use of circulating miRNAs as biomarkers for UTUC diagnosis, which remains to be verified by further studies.
publisher	D.A. Spandidos
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626156/
_version_	1613494901976072192

Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection

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