A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds

A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds

The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin inducers still have limited clinical indications. High-throughput screenings (HTS) aimed to identify new potentially therapeutic drugs require s...

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Bibliographic Details
Main Authors: Durlak, Marta, Fugazza, Cristina, Elangovan, Sudharshan, Marini, Maria Giuseppina, Marongiu, Maria Franca, Moi, Paolo, Fraietta, Ivan, Cappella, Paolo, Barbarani, Gloria, Font-Monclus, Isaura, Mauri, Mario, Ottolenghi, Sergio, Gasparri, Fabio, Ronchi, Antonella
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624791/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624791/

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