Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

Early-life stress (ELS) induces long-lasting changes in gene expression conferring an increased risk for the development of stress-related mental disorders. Glucocorticoid receptors (GR) mediate the negative feedback actions of glucocorticoids (GC) in the paraventricular nucleus (PVN) of the hypotha...

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Bibliographic Details
Main Authors: Bockmühl, Yvonne, Patchev, Alexandre V, Madejska, Arleta, Hoffmann, Anke, Sousa, Joao C, Sousa, Nuno, Holsboer, Florian, Almeida, Osborne F X, Spengler, Dietmar
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622987/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622987/

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