Functional assessment of antibody oxidation by native mass spectrometry

Functional assessment of antibody oxidation by native mass spectrometry

Oxidation of methionine (Met) residues is one of several chemical degradation pathways for recombinant IgG1 antibodies. Studies using several methodologies have indicated that Met oxidation in the constant IgG1 domains affects in vitro interaction with human neonatal Fc (huFcRn) receptor, which is i...

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Bibliographic Details
Main Authors: Haberger, Markus, Heidenreich, Anna-Katharina, Schlothauer, Tilman, Hook, Michaela, Gassner, Jana, Bomans, Katrin, Yegres, Michelle, Zwick, Adrian, Zimmermann, Boris, Wegele, Harald, Bonnington, Lea, Reusch, Dietmar, Bulau, Patrick
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622615/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622615/

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