YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice

YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice

Here we demonstrated that sepantronium bromide (YM155), a survivin suppressant, inhibited esophageal squamous-cell carcinoma (ESCC) growth in mice bearing human ESCC xenografts without affecting body weight. In cell culture, YM155 decreased survivin levels and caused PARP-1 activation, poly-ADP poly...

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Bibliographic Details
Main Authors: Zhao, Nan, Mao, Yousheng, Han, Gaijing, Ju, Qiang, Zhou, Lanping, Liu, Fang, Xu, Yang, Zhao, Xiaohang
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621902/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621902/

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