The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition
Upon offloading to Num1 cortical receptor sites in budding yeast, cytoplasmic dynein motility is switched “on” by a mechanism that likely involves Num1-mediated dissociation of the Pac1 inhibitor, a homologue of human LIS1.
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621840/ |