A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, Marfan mice treated with CCBs show accelerated aneurysm expansion, rupture, and p...

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Bibliographic Details
Main Authors: Doyle, Jefferson J, Doyle, Alexander J, Wilson, Nicole K, Habashi, Jennifer P, Bedja, Djahida, Whitworth, Ryan E, Lindsay, Mark E, Schoenhoff, Florian, Myers, Loretha, Huso, Nick, Bachir, Suha, Squires, Oliver, Rusholme, Benjamin, Ehsan, Hamid, Huso, David, Thomas, Craig J, Caulfield, Mark J, Van Eyk, Jennifer E, Judge, Daniel P, Dietz, Harry C
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621743/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621743/

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