Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis

Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis

The small G protein Arf6 and the GTPase dynamin2 (Dyn2) play key roles in clathrin-mediated endocytosis (CME). However, their functional relationship remains obscure. Here, we show that Arf6 functions as a downstream molecule of Dyn2 in CME. Wild type of Dyn2 overexpressed in HeLa cells markedly act...

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Bibliographic Details
Main Authors: Okada, Risa, Yamauchi, Yohei, Hongu, Tsunaki, Funakoshi, Yuji, Ohbayashi, Norihiko, Hasegawa, Hiroshi, Kanaho, Yasunori
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621509/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621509/

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