Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report

Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough...

Full description

Bibliographic Details
Main Authors:	Choi, Yeun Seoung, Lim, Jung Soo, Kwon, Woocheol, Jung, Soon-Hee, Park, Il Hwan, Lee, Myoung Kyu, Lee, Won Yeon, Yong, Suk Joong, Lee, Seok Jeong, Jung, Ye-Ryung, Choi, Jiwon, Choi, Ji Sun, Jeong, Joon Taek, Yoo, Jin Sae, Kim, Sang-Ha
Format:	Online
Language:	English
Published:	The Korean Academy of Tuberculosis and Respiratory Diseases 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620353/

id	pubmed-4620353
recordtype	oai_dc
spelling	pubmed-46203532015-10-27 Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report Choi, Yeun Seoung Lim, Jung Soo Kwon, Woocheol Jung, Soon-Hee Park, Il Hwan Lee, Myoung Kyu Lee, Won Yeon Yong, Suk Joong Lee, Seok Jeong Jung, Ye-Ryung Choi, Jiwon Choi, Ji Sun Jeong, Joon Taek Yoo, Jin Sae Kim, Sang-Ha Case Report Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus. The Korean Academy of Tuberculosis and Respiratory Diseases 2015-10 2015-10-01 /pmc/articles/PMC4620353/ /pubmed/26508947 http://dx.doi.org/10.4046/trd.2015.78.4.463 Text en Copyright©2015. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/)
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Choi, Yeun Seoung Lim, Jung Soo Kwon, Woocheol Jung, Soon-Hee Park, Il Hwan Lee, Myoung Kyu Lee, Won Yeon Yong, Suk Joong Lee, Seok Jeong Jung, Ye-Ryung Choi, Jiwon Choi, Ji Sun Jeong, Joon Taek Yoo, Jin Sae Kim, Sang-Ha
spellingShingle	Choi, Yeun Seoung Lim, Jung Soo Kwon, Woocheol Jung, Soon-Hee Park, Il Hwan Lee, Myoung Kyu Lee, Won Yeon Yong, Suk Joong Lee, Seok Jeong Jung, Ye-Ryung Choi, Jiwon Choi, Ji Sun Jeong, Joon Taek Yoo, Jin Sae Kim, Sang-Ha Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
author_facet	Choi, Yeun Seoung Lim, Jung Soo Kwon, Woocheol Jung, Soon-Hee Park, Il Hwan Lee, Myoung Kyu Lee, Won Yeon Yong, Suk Joong Lee, Seok Jeong Jung, Ye-Ryung Choi, Jiwon Choi, Ji Sun Jeong, Joon Taek Yoo, Jin Sae Kim, Sang-Ha
author_sort	Choi, Yeun Seoung
title	Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
title_short	Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
title_full	Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
title_fullStr	Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
title_full_unstemmed	Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
title_sort	pulmonary langerhans cell histiocytosis in an adult male presenting with central diabetes insipidus and diabetes mellitus: a case report
description	Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
publisher	The Korean Academy of Tuberculosis and Respiratory Diseases
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620353/
_version_	1613492997123473408

Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report

Similar Items