Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease
Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gam...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619955/ |
| id |
pubmed-4619955 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-46199552015-11-04 Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease Hasan, Md. Samiul Bergmeier, Lesley Ann Petrushkin, Harry Fortune, Farida Review Article Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis. Hindawi Publishing Corporation 2015 2015-10-11 /pmc/articles/PMC4619955/ /pubmed/26539557 http://dx.doi.org/10.1155/2015/705831 Text en Copyright © 2015 Md. Samiul Hasan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hasan, Md. Samiul Bergmeier, Lesley Ann Petrushkin, Harry Fortune, Farida |
| spellingShingle |
Hasan, Md. Samiul Bergmeier, Lesley Ann Petrushkin, Harry Fortune, Farida Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| author_facet |
Hasan, Md. Samiul Bergmeier, Lesley Ann Petrushkin, Harry Fortune, Farida |
| author_sort |
Hasan, Md. Samiul |
| title |
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| title_short |
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| title_full |
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| title_fullStr |
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| title_full_unstemmed |
Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease |
| title_sort |
gamma delta (γδ) t cells and their involvement in behçet's disease |
| description |
Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619955/ |
| _version_ |
1613492858661109760 |