Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components

Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number chan...

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Main Authors:	Carvalho, Beatriz, Buffart, Tineke E., Reis, Rui M., Mons, Thomas, Moutinho, Cátia, Silva, Paula, van Grieken, Nicole C. T., Grabsch, Heike, van de Velde, Cornelis J. H., Ylstra, Bauke, Meijer, Gerrit A., Carneiro, Fátima
Format:	Online
Language:	English
Published:	IOS Press 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617807/

id	pubmed-4617807
recordtype	oai_dc
spelling	pubmed-46178072016-01-12 Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components Carvalho, Beatriz Buffart, Tineke E. Reis, Rui M. Mons, Thomas Moutinho, Cátia Silva, Paula van Grieken, Nicole C. T. Grabsch, Heike van de Velde, Cornelis J. H. Ylstra, Bauke Meijer, Gerrit A. Carneiro, Fátima Other Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray – comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations. IOS Press 2006 2006-12-12 /pmc/articles/PMC4617807/ /pubmed/17167181 http://dx.doi.org/10.1155/2006/650620 Text en Copyright © 2006 Hindawi Publishing Corporation and the authors.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Carvalho, Beatriz Buffart, Tineke E. Reis, Rui M. Mons, Thomas Moutinho, Cátia Silva, Paula van Grieken, Nicole C. T. Grabsch, Heike van de Velde, Cornelis J. H. Ylstra, Bauke Meijer, Gerrit A. Carneiro, Fátima
spellingShingle	Carvalho, Beatriz Buffart, Tineke E. Reis, Rui M. Mons, Thomas Moutinho, Cátia Silva, Paula van Grieken, Nicole C. T. Grabsch, Heike van de Velde, Cornelis J. H. Ylstra, Bauke Meijer, Gerrit A. Carneiro, Fátima Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
author_facet	Carvalho, Beatriz Buffart, Tineke E. Reis, Rui M. Mons, Thomas Moutinho, Cátia Silva, Paula van Grieken, Nicole C. T. Grabsch, Heike van de Velde, Cornelis J. H. Ylstra, Bauke Meijer, Gerrit A. Carneiro, Fátima
author_sort	Carvalho, Beatriz
title	Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
title_short	Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
title_full	Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
title_fullStr	Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
title_full_unstemmed	Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
title_sort	mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components
description	Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray – comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations.
publisher	IOS Press
publishDate	2006
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617807/
_version_	1613491951255945216

Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components

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