Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]

Xanthine-based KMUP-1 improves HDL via PPARĪ³/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]

The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia. We compared its lipid-lowering effects with simvastatin and explored hormone-sensitive lipase (HSL) translocation in hepatic fat loss. KMUP-1 HCl (1, 2.5, and 5 mg/kg/da...

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Bibliographic Details
Main Authors: Kuo, Kung-Kai, Wu, Bin-Nan, Liu, Chung-Pin, Yang, Tzu-Yang, Kao, Li-Pin, Wu, Jiunn-Ren, Lai, Wen-Ter, Chen, Ing-Jun
Format: Online
Language:English
Published: The American Society for Biochemistry and Molecular Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617394/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617394/

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