Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly

Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly

Emerging evidences showed impaired muscle strength was prevalent in older adults with mild cognition impairment or dementia. However, little was known about the role of quadriceps strength in the cognition decline among older population. The objective of our study was to investigate the relation bet...

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Main Authors: Chen, Wei-Liang, Peng, Tao-Chun, Sun, Yu-Shan, Yang, Hui-Fang, Liaw, Fang-Yih, Wu, Li-Wei, Chang, Yaw-Wen, Kao, Tung-Wei
Format: Online
Language:English
Published: Wolters Kluwer Health 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616681/
id pubmed-4616681
recordtype oai_dc
spelling pubmed-46166812015-10-27 Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly Chen, Wei-Liang Peng, Tao-Chun Sun, Yu-Shan Yang, Hui-Fang Liaw, Fang-Yih Wu, Li-Wei Chang, Yaw-Wen Kao, Tung-Wei 5300 Emerging evidences showed impaired muscle strength was prevalent in older adults with mild cognition impairment or dementia. However, little was known about the role of quadriceps strength in the cognition decline among older population. The objective of our study was to investigate the relation between quadriceps strength and cognitive performance. Using data from the National Health and Nutrition Examination Survey (1999–2002), a total of 1799 participants aged ≥60 years were enrolled in the study. Every subject completed a household interview, digit symbol substitution test (DSST), physical performances, and a questionnaire regarding personal health. Estimation of relationship between quadriceps strength and cognition was using multiple linear regression and quartile-based analysis with an extended-model approach for covariates adjustment. In a model adjusted for demographics, chronic diseases, health behaviors, and levels of folate and vitamin B12, the level of quadriceps strength was significantly associated with the scores of DSST. The β coefficient interpreted as change of DSST scores for each Newton increment in quadriceps strength comparing participants in the highest quartile of quadriceps strength to those in the lowest quartile was 5.003 (95% confidence interval, 2.725–7.281, P < 0.001). The trends of incremental DSST score across increasing quartiles of quadriceps strength were statistically significant (all P for trend <0.001). Higher quadriceps strength was associated with better cognitive performance. Wolters Kluwer Health 2015-08-14 /pmc/articles/PMC4616681/ /pubmed/26266380 http://dx.doi.org/10.1097/MD.0000000000001335 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Chen, Wei-Liang
Peng, Tao-Chun
Sun, Yu-Shan
Yang, Hui-Fang
Liaw, Fang-Yih
Wu, Li-Wei
Chang, Yaw-Wen
Kao, Tung-Wei
spellingShingle Chen, Wei-Liang
Peng, Tao-Chun
Sun, Yu-Shan
Yang, Hui-Fang
Liaw, Fang-Yih
Wu, Li-Wei
Chang, Yaw-Wen
Kao, Tung-Wei
Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
author_facet Chen, Wei-Liang
Peng, Tao-Chun
Sun, Yu-Shan
Yang, Hui-Fang
Liaw, Fang-Yih
Wu, Li-Wei
Chang, Yaw-Wen
Kao, Tung-Wei
author_sort Chen, Wei-Liang
title Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
title_short Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
title_full Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
title_fullStr Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
title_full_unstemmed Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly
title_sort examining the association between quadriceps strength and cognitive performance in the elderly
description Emerging evidences showed impaired muscle strength was prevalent in older adults with mild cognition impairment or dementia. However, little was known about the role of quadriceps strength in the cognition decline among older population. The objective of our study was to investigate the relation between quadriceps strength and cognitive performance. Using data from the National Health and Nutrition Examination Survey (1999–2002), a total of 1799 participants aged ≥60 years were enrolled in the study. Every subject completed a household interview, digit symbol substitution test (DSST), physical performances, and a questionnaire regarding personal health. Estimation of relationship between quadriceps strength and cognition was using multiple linear regression and quartile-based analysis with an extended-model approach for covariates adjustment. In a model adjusted for demographics, chronic diseases, health behaviors, and levels of folate and vitamin B12, the level of quadriceps strength was significantly associated with the scores of DSST. The β coefficient interpreted as change of DSST scores for each Newton increment in quadriceps strength comparing participants in the highest quartile of quadriceps strength to those in the lowest quartile was 5.003 (95% confidence interval, 2.725–7.281, P < 0.001). The trends of incremental DSST score across increasing quartiles of quadriceps strength were statistically significant (all P for trend <0.001). Higher quadriceps strength was associated with better cognitive performance.
publisher Wolters Kluwer Health
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616681/
_version_ 1613491595164778496

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