Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis

Constipation is a common childhood complaint. In 90% to 95% of children, constipation is functional, which means that there is no objective evidence of an underlying pathological condition. Polyethylene glycol (PEG or macrogol) solution is an osmotic laxative agent that is absorbed in only trace amo...

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Main Authors:	Chen, Si-Le, Cai, Shi-Rong, Deng, Liang, Zhang, Xin-Hua, Luo, Te-Dong, Peng, Jian-Jun, Xu, Jian-Bo, Li, Wen-Feng, Chen, Chuang-Qi, Ma, Jin-Ping, He, Yu-Long
Format:	Online
Language:	English
Published:	Wolters Kluwer Health 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616298/

id	pubmed-4616298
recordtype	oai_dc
spelling	pubmed-46162982015-10-27 Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis Chen, Si-Le Cai, Shi-Rong Deng, Liang Zhang, Xin-Hua Luo, Te-Dong Peng, Jian-Jun Xu, Jian-Bo Li, Wen-Feng Chen, Chuang-Qi Ma, Jin-Ping He, Yu-Long Article Constipation is a common childhood complaint. In 90% to 95% of children, constipation is functional, which means that there is no objective evidence of an underlying pathological condition. Polyethylene glycol (PEG or macrogol) solution is an osmotic laxative agent that is absorbed in only trace amounts from the gastrointestinal tract and routinely used to treat chronic constipation in adults. Here, we report the results of a meta-analysis of PEG-based laxatives compared with lactulose, milk of magnesia (magnesium hydroxide), oral liquid paraffin (mineral oil), or acacia fiber, psyllium fiber, and fructose in children. Wolters Kluwer Health 2014-10-03 /pmc/articles/PMC4616298/ /pubmed/25310742 http://dx.doi.org/10.1097/MD.0000000000000065 Text en © 2014 Wolters Kluwer Health \| Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chen, Si-Le Cai, Shi-Rong Deng, Liang Zhang, Xin-Hua Luo, Te-Dong Peng, Jian-Jun Xu, Jian-Bo Li, Wen-Feng Chen, Chuang-Qi Ma, Jin-Ping He, Yu-Long
spellingShingle	Chen, Si-Le Cai, Shi-Rong Deng, Liang Zhang, Xin-Hua Luo, Te-Dong Peng, Jian-Jun Xu, Jian-Bo Li, Wen-Feng Chen, Chuang-Qi Ma, Jin-Ping He, Yu-Long Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
author_facet	Chen, Si-Le Cai, Shi-Rong Deng, Liang Zhang, Xin-Hua Luo, Te-Dong Peng, Jian-Jun Xu, Jian-Bo Li, Wen-Feng Chen, Chuang-Qi Ma, Jin-Ping He, Yu-Long
author_sort	Chen, Si-Le
title	Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
title_short	Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
title_full	Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
title_fullStr	Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
title_full_unstemmed	Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis
title_sort	efficacy and complications of polyethylene glycols for treatment of constipation in children: a meta-analysis
description	Constipation is a common childhood complaint. In 90% to 95% of children, constipation is functional, which means that there is no objective evidence of an underlying pathological condition. Polyethylene glycol (PEG or macrogol) solution is an osmotic laxative agent that is absorbed in only trace amounts from the gastrointestinal tract and routinely used to treat chronic constipation in adults. Here, we report the results of a meta-analysis of PEG-based laxatives compared with lactulose, milk of magnesia (magnesium hydroxide), oral liquid paraffin (mineral oil), or acacia fiber, psyllium fiber, and fructose in children.
publisher	Wolters Kluwer Health
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616298/
_version_	1613491382709649408

Efficacy and Complications of Polyethylene Glycols for Treatment of Constipation in Children: A Meta-Analysis

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