Probing the closed-loop model of mRNA translation in living cells

The mRNA closed-loop, formed through interactions between the cap structure, poly(A) tail, eIF4E, eIF4G and PAB, features centrally in models of eukaryotic translation initiation, although direct support for its existence in vivo is not well established. Here, we investigated the closed-loop using a...

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Bibliographic Details
Main Authors: Archer, Stuart K, Shirokikh, Nikolay E, Hallwirth, Claus V, Beilharz, Traude H, Preiss, Thomas
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615164/