XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

The limitations of cancer cell lines have led to the development of direct patient derived xenograft (PDX) models. However, the interplay between the implanted human cancer cells and recruited mouse stromal and immune cells alters the tumor microenvironment and limits the value of these models. To o...

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Bibliographic Details
Main Authors: Morton, J. Jason, Bird, Gregory, Keysar, Stephen B., Astling, David P., Lyons, Traci R, Anderson, Ryan T., Glogowska, Magdalena J., Estes, Patricia, Eagles, Justin R., Le, Phuong N., Gan, Gregory, McGettigan, Brett, Fernandez, Pamela, Padilla-Just, Nuria, Varella-Garcia, Marileila, Song, John I., Bowles, Daniel W., Schedin, Pepper, Tan, Aik-Choon, Roop, Dennis R., Wang, Xiao-Jing, Refaeli, Yosef, Jimeno, Antonio
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613815/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613815/

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