The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

Receptor-interacting protein (RIP)3 is a critical regulator of necroptosis and has been demonstrated to be associated with various diseases, suggesting that its inhibitors are promising in the clinic. However, there have been few RIP3 inhibitors reported as yet. B-RafV600E inhibitors are an importan...

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Bibliographic Details
Main Authors: Li, J-X, Feng, J-M, Wang, Y, Li, X-H, Chen, X-X, Su, Y, Shen, Y-Y, Chen, Y, Xiong, B, Yang, C-H, Ding, J, Miao, Z-H
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611716/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611716/

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