Bone Regeneration from PLGA Micro-Nanoparticles

Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of...

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Main Authors:	Ortega-Oller, Inmaculada, Padial-Molina, Miguel, Galindo-Moreno, Pablo, O'Valle, Francisco, Jódar-Reyes, Ana Belén, Peula-García, Jose Manuel
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609778/

id	pubmed-4609778
recordtype	oai_dc
spelling	pubmed-46097782015-10-27 Bone Regeneration from PLGA Micro-Nanoparticles Ortega-Oller, Inmaculada Padial-Molina, Miguel Galindo-Moreno, Pablo O'Valle, Francisco Jódar-Reyes, Ana Belén Peula-García, Jose Manuel Review Article Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed. Hindawi Publishing Corporation 2015 2015-10-05 /pmc/articles/PMC4609778/ /pubmed/26509156 http://dx.doi.org/10.1155/2015/415289 Text en Copyright © 2015 Inmaculada Ortega-Oller et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ortega-Oller, Inmaculada Padial-Molina, Miguel Galindo-Moreno, Pablo O'Valle, Francisco Jódar-Reyes, Ana Belén Peula-García, Jose Manuel
spellingShingle	Ortega-Oller, Inmaculada Padial-Molina, Miguel Galindo-Moreno, Pablo O'Valle, Francisco Jódar-Reyes, Ana Belén Peula-García, Jose Manuel Bone Regeneration from PLGA Micro-Nanoparticles
author_facet	Ortega-Oller, Inmaculada Padial-Molina, Miguel Galindo-Moreno, Pablo O'Valle, Francisco Jódar-Reyes, Ana Belén Peula-García, Jose Manuel
author_sort	Ortega-Oller, Inmaculada
title	Bone Regeneration from PLGA Micro-Nanoparticles
title_short	Bone Regeneration from PLGA Micro-Nanoparticles
title_full	Bone Regeneration from PLGA Micro-Nanoparticles
title_fullStr	Bone Regeneration from PLGA Micro-Nanoparticles
title_full_unstemmed	Bone Regeneration from PLGA Micro-Nanoparticles
title_sort	bone regeneration from plga micro-nanoparticles
description	Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609778/
_version_	1613489576300511232

Bone Regeneration from PLGA Micro-Nanoparticles

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