Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release

Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release

Knockout serum replacement (KOSR) is a nutrient supplement commonly used to replace serum for culturing stem cells. We show here that KOSR has pro-survival activity in chronic myelogenous leukemia (CML) cells transformed by the BCR-ABL oncogene. Inhibitors of BCR-ABL tyrosine kinase kill CML cells b...

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Bibliographic Details
Main Authors: Ishii, Yuki, Nhiayi, May Keu, Tse, Edison, Cheng, Jonathan, Massimino, Michele, Durden, Donald L., Vigneri, Paolo, Wang, Jean Y. J.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608728/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608728/

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