LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes

Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite, Trypanosoma brucei. In the mammalian bloodstream, the trypanosome’s metabolism differs significantly from that of its host. For example, the parasite relies exclusively on glycolysis for energy source. Re...

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Bibliographic Details
Main Authors: Kim, Dong-Hyun, Achcar, Fiona, Breitling, Rainer, Burgess, Karl E., Barrett, Michael P.
Format: Online
Language:English
Published: Springer US 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605981/