Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylate...

Full description

Bibliographic Details
Main Authors: Perugino, Giuseppe, Miggiano, Riccardo, Serpe, Mario, Vettone, Antonella, Valenti, Anna, Lahiri, Samarpita, Rossi, Franca, Rossi, Mosè, Rizzi, Menico, Ciaramella, Maria
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605297/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605297/

Similar Items