Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from Janu...
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Wolters Kluwer Health
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602699/ |
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pubmed-4602699 |
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pubmed-46026992015-10-27 Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients Zhao, Yun Li, Ya Wang, Li Li, Xiao-Feng Huang, Ci-Bo Wang, Guo-Chun Zhang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Xiao, Wei-Guo Dai, Lie Wang, Yong-Fu Hu, Shao-Xian Li, Hong-Bin Gong, Lu Liu, Bin Sun, Ling-Yun Zhang, Miao-Jia Zhang, Xuan Li, Yong-Zhe Du, De-Shun Zhang, Shun-Hua Sun, Yuan-Yuan Zhang, Feng-Chun 6900 The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement, and autoimmunity in these patients. The cohort included 456 women and 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median age at diagnosis, 49 years; range, 41–56 years). Male patients showed a lower frequency of xerophthalmia (37.0% vs 60.7%) and a higher frequency of arthritis (40.7% vs 16.4%). Young-onset patients showed a higher frequency of low C3 levels (57.7% vs 36.3%) and pancytopenia (22.2% vs 8.8%). Patients with systemic involvement had a higher frequency of immunoglobulin A (IgA) (39.4% vs 22.5%) and immunoglobulin M (IgM) (12.4% vs 37.9%). Patients with pulmonary involvement had a higher parotid enlargement (21.4% vs 10.2%), purpura (12.1% vs 5.7%) and higher anti-La/SS-B (61.7% vs 41.8%), immunoglobulin G (IgG) (80.7% vs 64.6%) and IgA (48.9% vs 30.6%) levels. Patients with anti-Ro/SSA antibodies had more frequent exocrine gland symptoms and some extraglandular symptoms and immunological alterations. Compared with previous studies performed in other countries, SS patients in China showed particular clinical manifestation, systemic involvement, and immunological alterations. Wolters Kluwer Health 2015-04-24 /pmc/articles/PMC4602699/ /pubmed/25906094 http://dx.doi.org/10.1097/MD.0000000000000667 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhao, Yun Li, Ya Wang, Li Li, Xiao-Feng Huang, Ci-Bo Wang, Guo-Chun Zhang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Xiao, Wei-Guo Dai, Lie Wang, Yong-Fu Hu, Shao-Xian Li, Hong-Bin Gong, Lu Liu, Bin Sun, Ling-Yun Zhang, Miao-Jia Zhang, Xuan Li, Yong-Zhe Du, De-Shun Zhang, Shun-Hua Sun, Yuan-Yuan Zhang, Feng-Chun |
| spellingShingle |
Zhao, Yun Li, Ya Wang, Li Li, Xiao-Feng Huang, Ci-Bo Wang, Guo-Chun Zhang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Xiao, Wei-Guo Dai, Lie Wang, Yong-Fu Hu, Shao-Xian Li, Hong-Bin Gong, Lu Liu, Bin Sun, Ling-Yun Zhang, Miao-Jia Zhang, Xuan Li, Yong-Zhe Du, De-Shun Zhang, Shun-Hua Sun, Yuan-Yuan Zhang, Feng-Chun Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| author_facet |
Zhao, Yun Li, Ya Wang, Li Li, Xiao-Feng Huang, Ci-Bo Wang, Guo-Chun Zhang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Xiao, Wei-Guo Dai, Lie Wang, Yong-Fu Hu, Shao-Xian Li, Hong-Bin Gong, Lu Liu, Bin Sun, Ling-Yun Zhang, Miao-Jia Zhang, Xuan Li, Yong-Zhe Du, De-Shun Zhang, Shun-Hua Sun, Yuan-Yuan Zhang, Feng-Chun |
| author_sort |
Zhao, Yun |
| title |
Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| title_short |
Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| title_full |
Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| title_fullStr |
Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| title_full_unstemmed |
Primary Sjögren Syndrome in Han Chinese: Clinical and Immunological Characteristics of 483 Patients |
| title_sort |
primary sjögren syndrome in han chinese: clinical and immunological characteristics of 483 patients |
| description |
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement, and autoimmunity in these patients. The cohort included 456 women and 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median age at diagnosis, 49 years; range, 41–56 years). Male patients showed a lower frequency of xerophthalmia (37.0% vs 60.7%) and a higher frequency of arthritis (40.7% vs 16.4%). Young-onset patients showed a higher frequency of low C3 levels (57.7% vs 36.3%) and pancytopenia (22.2% vs 8.8%). Patients with systemic involvement had a higher frequency of immunoglobulin A (IgA) (39.4% vs 22.5%) and immunoglobulin M (IgM) (12.4% vs 37.9%). Patients with pulmonary involvement had a higher parotid enlargement (21.4% vs 10.2%), purpura (12.1% vs 5.7%) and higher anti-La/SS-B (61.7% vs 41.8%), immunoglobulin G (IgG) (80.7% vs 64.6%) and IgA (48.9% vs 30.6%) levels. Patients with anti-Ro/SSA antibodies had more frequent exocrine gland symptoms and some extraglandular symptoms and immunological alterations. Compared with previous studies performed in other countries, SS patients in China showed particular clinical manifestation, systemic involvement, and immunological alterations. |
| publisher |
Wolters Kluwer Health |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602699/ |
| _version_ |
1613487019132977152 |