A mouse informatics platform for phenotypic and translational discovery

The International Mouse Phenotyping Consortium (IMPC) is providing the world’s first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene. A robust and highly structured informatics platform has been developed to systematically collate, analyse and diss...

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Main Authors:	Ring, Natalie, Meehan, Terrence F., Blake, Andrew, Brown, James, Chen, Chao-Kung, Conte, Nathalie, Di Fenza, Armida, Fiegel, Tanja, Horner, Neil, Jacobsen, Julius O. B., Karp, Natasha, Lawson, Thomas, Mason, Jeremy C., Matthews, Peter, Morgan, Hugh, Relac, Mike, Santos, Luis, Smedley, Damian, Sneddon, Duncan, Pengelly, Alice, Tudose, Ilinca, Warren, Jonathan W. G., Westerberg, Henrik, Yaikhom, Gagarine, Parkinson, Helen, Mallon, Ann-Marie
Format:	Online
Language:	English
Published:	Springer US 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602054/

id	pubmed-4602054
recordtype	oai_dc
spelling	pubmed-46020542015-10-16 A mouse informatics platform for phenotypic and translational discovery Ring, Natalie Meehan, Terrence F. Blake, Andrew Brown, James Chen, Chao-Kung Conte, Nathalie Di Fenza, Armida Fiegel, Tanja Horner, Neil Jacobsen, Julius O. B. Karp, Natasha Lawson, Thomas Mason, Jeremy C. Matthews, Peter Morgan, Hugh Relac, Mike Santos, Luis Smedley, Damian Sneddon, Duncan Pengelly, Alice Tudose, Ilinca Warren, Jonathan W. G. Westerberg, Henrik Yaikhom, Gagarine Parkinson, Helen Mallon, Ann-Marie Article The International Mouse Phenotyping Consortium (IMPC) is providing the world’s first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene. A robust and highly structured informatics platform has been developed to systematically collate, analyse and disseminate the data produced by the IMPC. As the first phase of the project, in which 5000 new knockout strains are being broadly phenotyped, nears completion, the informatics platform is extending and adapting to support the increasing volume and complexity of the data produced as well as addressing a large volume of users and emerging user groups. An intuitive interface helps researchers explore IMPC data by giving overviews and the ability to find and visualise data that support a phenotype assertion. Dedicated disease pages allow researchers to find new mouse models of human diseases, and novel viewers provide high-resolution images of embryonic and adult dysmorphologies. With each monthly release, the informatics platform will continue to evolve to support the increased data volume and to maintain its position as the primary route of access to IMPC data and as an invaluable resource for clinical and non-clinical researchers. Springer US 2015-08-28 2015 /pmc/articles/PMC4602054/ /pubmed/26314589 http://dx.doi.org/10.1007/s00335-015-9599-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ring, Natalie Meehan, Terrence F. Blake, Andrew Brown, James Chen, Chao-Kung Conte, Nathalie Di Fenza, Armida Fiegel, Tanja Horner, Neil Jacobsen, Julius O. B. Karp, Natasha Lawson, Thomas Mason, Jeremy C. Matthews, Peter Morgan, Hugh Relac, Mike Santos, Luis Smedley, Damian Sneddon, Duncan Pengelly, Alice Tudose, Ilinca Warren, Jonathan W. G. Westerberg, Henrik Yaikhom, Gagarine Parkinson, Helen Mallon, Ann-Marie
spellingShingle	Ring, Natalie Meehan, Terrence F. Blake, Andrew Brown, James Chen, Chao-Kung Conte, Nathalie Di Fenza, Armida Fiegel, Tanja Horner, Neil Jacobsen, Julius O. B. Karp, Natasha Lawson, Thomas Mason, Jeremy C. Matthews, Peter Morgan, Hugh Relac, Mike Santos, Luis Smedley, Damian Sneddon, Duncan Pengelly, Alice Tudose, Ilinca Warren, Jonathan W. G. Westerberg, Henrik Yaikhom, Gagarine Parkinson, Helen Mallon, Ann-Marie A mouse informatics platform for phenotypic and translational discovery
author_facet	Ring, Natalie Meehan, Terrence F. Blake, Andrew Brown, James Chen, Chao-Kung Conte, Nathalie Di Fenza, Armida Fiegel, Tanja Horner, Neil Jacobsen, Julius O. B. Karp, Natasha Lawson, Thomas Mason, Jeremy C. Matthews, Peter Morgan, Hugh Relac, Mike Santos, Luis Smedley, Damian Sneddon, Duncan Pengelly, Alice Tudose, Ilinca Warren, Jonathan W. G. Westerberg, Henrik Yaikhom, Gagarine Parkinson, Helen Mallon, Ann-Marie
author_sort	Ring, Natalie
title	A mouse informatics platform for phenotypic and translational discovery
title_short	A mouse informatics platform for phenotypic and translational discovery
title_full	A mouse informatics platform for phenotypic and translational discovery
title_fullStr	A mouse informatics platform for phenotypic and translational discovery
title_full_unstemmed	A mouse informatics platform for phenotypic and translational discovery
title_sort	mouse informatics platform for phenotypic and translational discovery
description	The International Mouse Phenotyping Consortium (IMPC) is providing the world’s first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene. A robust and highly structured informatics platform has been developed to systematically collate, analyse and disseminate the data produced by the IMPC. As the first phase of the project, in which 5000 new knockout strains are being broadly phenotyped, nears completion, the informatics platform is extending and adapting to support the increasing volume and complexity of the data produced as well as addressing a large volume of users and emerging user groups. An intuitive interface helps researchers explore IMPC data by giving overviews and the ability to find and visualise data that support a phenotype assertion. Dedicated disease pages allow researchers to find new mouse models of human diseases, and novel viewers provide high-resolution images of embryonic and adult dysmorphologies. With each monthly release, the informatics platform will continue to evolve to support the increased data volume and to maintain its position as the primary route of access to IMPC data and as an invaluable resource for clinical and non-clinical researchers.
publisher	Springer US
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602054/
_version_	1613486704779329536

A mouse informatics platform for phenotypic and translational discovery

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