Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction
Lateral associations between inactive αv integrin and Thy-1 glycoprotein control integrin avidity to extracellular matrix ligand, the localization and kinetics of downstream signal activity, and mechanosensitive remodeling of the cytoskeleton.
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602038/ |