Epithelial junctions and Rho family GTPases: the zonular signalosome
The establishment and maintenance of epithelial cell-cell junctions is crucially important to regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls the architecture and physiology of epithelial organs. Junctions are supported, shaped and regulated by cytos...
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| Format: | Online |
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Taylor & Francis
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601189/ |
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pubmed-46011892016-02-03 Epithelial junctions and Rho family GTPases: the zonular signalosome Citi, Sandra Guerrera, Diego Spadaro, Domenica Shah, Jimit Review The establishment and maintenance of epithelial cell-cell junctions is crucially important to regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls the architecture and physiology of epithelial organs. Junctions are supported, shaped and regulated by cytoskeletal filaments, whose dynamic organization and contractility are finely tuned by GTPases of the Rho family, primarily RhoA, Rac1 and Cdc42. Recent research has identified new molecular mechanisms underlying the cross-talk between these GTPases and epithelial junctions. Here we briefly summarize the current knowledge about the organization, molecular evolution and cytoskeletal anchoring of cell-cell junctions, and we comment on the most recent advances in the characterization of the interactions between Rho GTPases and junctional proteins, and their consequences with regards to junction assembly and regulation of cell behavior in vertebrate model systems. The concept of “zonular signalosome” is proposed, which highlights the close functional relationship between proteins of zonular junctions (zonulae occludentes and adhaerentes) and the control of cytoskeletal organization and signaling through Rho GTPases, transcription factors, and their effectors. Taylor & Francis 2014-11-11 /pmc/articles/PMC4601189/ /pubmed/25483301 http://dx.doi.org/10.4161/21541248.2014.973760 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Citi, Sandra Guerrera, Diego Spadaro, Domenica Shah, Jimit |
| spellingShingle |
Citi, Sandra Guerrera, Diego Spadaro, Domenica Shah, Jimit Epithelial junctions and Rho family GTPases: the zonular signalosome |
| author_facet |
Citi, Sandra Guerrera, Diego Spadaro, Domenica Shah, Jimit |
| author_sort |
Citi, Sandra |
| title |
Epithelial junctions and Rho family GTPases: the zonular signalosome |
| title_short |
Epithelial junctions and Rho family GTPases: the zonular signalosome |
| title_full |
Epithelial junctions and Rho family GTPases: the zonular signalosome |
| title_fullStr |
Epithelial junctions and Rho family GTPases: the zonular signalosome |
| title_full_unstemmed |
Epithelial junctions and Rho family GTPases: the zonular signalosome |
| title_sort |
epithelial junctions and rho family gtpases: the zonular signalosome |
| description |
The establishment and maintenance of epithelial cell-cell junctions is crucially important to regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls the architecture and physiology of epithelial organs. Junctions are supported, shaped and regulated by cytoskeletal filaments, whose dynamic organization and contractility are finely tuned by GTPases of the Rho family, primarily RhoA, Rac1 and Cdc42. Recent research has identified new molecular mechanisms underlying the cross-talk between these GTPases and epithelial junctions. Here we briefly summarize the current knowledge about the organization, molecular evolution and cytoskeletal anchoring of cell-cell junctions, and we comment on the most recent advances in the characterization of the interactions between Rho GTPases and junctional proteins, and their consequences with regards to junction assembly and regulation of cell behavior in vertebrate model systems. The concept of “zonular signalosome” is proposed, which highlights the close functional relationship between proteins of zonular junctions (zonulae occludentes and adhaerentes) and the control of cytoskeletal organization and signaling through Rho GTPases, transcription factors, and their effectors. |
| publisher |
Taylor & Francis |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601189/ |
| _version_ |
1613486425450217472 |